Chromokinesin

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August undefined, 2024

WebMar 16, 2024 · The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain … WebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the …

Chromokinesins: multitalented players in mitosis - ScienceDirect

WebSep 21, 2005 · The human chromokinesin Kid/Kinesin-10 is a plus end-directed MT-based motor ( Shiroguchi et al ., 2003; Yajima et al ., 2003) that binds both MTs and chromosomes ( Tokai et al ., 1996 ). Kid has been reported to play an important role in chromosomal movement along MTs during prometaphase and metaphase. WebBackground: Despite the significant survival benefits of anti-PD-1/PD-L1 immunotherapy, non-small cell lung cancer (NSCLC) remains one of the most common tumors and major causes of cancer-related deaths worldwide. Thus, there is an urgent need to identify new therapeutic targets for this refractory disease. Methods: In this study, microarray datasets … portland youth climate summit

Chromokinesins: multitalented players in mitosis - PubMed

WebJan 1, 2024 · Abstract The chromokinesin KIF22 (Kid, kinesin-10 family) is the primary generator of polar ejection forces, which contribute to chromosome positioning and alignment in mitotic cells. Assessment of KIF22 function requires quantitative comparison of relative polar ejection forces between experimental conditions. WebThe chromokinesins are a subgroup of kinesin motors. Chromokinesins act in various steps of mitosis, including chromosome condensation, metaphase alignment, chromosome segregation, cytokinesis and they help maintain genome stability. WebMar 16, 2024 · The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient with a novel mutation in the KIF22 tail. We demonstrate that … option ot7815wh seat and cover

Pathogenic mutations in the chromokinesin KIF22 disrupt ... - bioRxiv

Chromokinesin KIF4A teams up with stathmin 1 to regulate …

WebJul 16, 1996 · The Kinesin-4 (formerly Chromokinesin/KIF4) family tree was obtained using the heuristic search method of PAUP v4.0b10 (Swofford, 2002), a maximum parsimony program, and random stepwise addition. The tree is one of two optimal trees that resulted from 600 trees that were built. The bootstrap values adjacent to the nodes are the … WebMay 1, 2016 · Chromokinesin contains both a kinesin motor-like domain and an unusual basic-leucine zipper DNA-binding domain. Its mRNA is readily detectable in proliferating cells, but not in postmitotic cells. option otcWebMar 6, 2015 · The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell 102, 411–424 (2000) . portland zoning ex

"WebApr 8, 2024 · This bias was impervious to the experimental attenuation of polar ejection forces on chromosome arms by RNAi against the chromokinesin Kif4a. Thus, kinetochore size is an important determinant of ... " - Chromokinesin

Chromokinesin

WebMar 6, 2015 · With regard to the kinetochore reaching the microtubule tip, CENP-E and chromokinesins are particularly important for chromosome movement to the spindle midzone in metazoans (Craske and Welburn,... WebSep 30, 2024 · The chromokinesin KIF22 uses plus end-directed motility and direct binding to chromosome arms to generate pushing forces that contribute to mitotic chromosome …

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WebThe chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient with a novel mutation in the KIF22 tail. WebThe chromokinesin KIF22 (Kid, kinesin-10 family) is the primary generator of polar ejection forces, which contribute to chromosome positioning and alignment in mitotic cells. Assessment of KIF22 function requires quantitative comparison of relative polar ejection forces between experimental conditions. This is facilitated by the generation of ...

WebOct 3, 2003 · Mitosis requires the concerted activities of multiple microtubule (MT)-based motor proteins. Here we examined the contribution of the chromokinesin, KLP3A, to mitotic spindle morphogenesis and chromosome movements in Drosophila embryos and cultured S2 cells. By immunofluorescence, KLP3A associates with nonfibrous punctae that … WebAug 14, 2010 · Chromokinesin KIF4 appears as reduced expression in human gastric carcinoma and associates with differentiation of gastric carcinoma. Chromokinesin KIF4 is previously reported to play an intriguing role in tumorigenesis [].To investigate the critical role of chromokinesin KIF4 in human gastric cancer, we examined 23 gastric carcinoma …

WebMay 12, 2024 · Chromokinesins are motor proteins that interact with both microtubules and chromatin ( Mazumdar and Misteli, 2005; Vanneste et al., 2011 ). Two well-characterized chromokinesin genes in Drosophila are the kinesin-10–related motor Nod ( Theurkauf and Hawley, 1992) and the kinesin-4–related motor Klp3a ( Williams et al., 1995 ). WebJul 24, 2024 · (A) Chromokinesin KIF4A is required for the positioning of mitotic chromosomes and stabilization of the bipolar spindle. In cytokinesis, KIF4A localizes at …

WebHere, we describe a live-cell PEF assay in which tension was applied to chromosomes by manipulating levels of the chromokinesin NOD (no distributive disjunction; Drosophila m... More Keywords. Article Link > Most Popular Services. Homology-Directed Repair (HDR) Knock-in Templates. CRISPR Cas9 Single guide RNA (sgRNA) and Ribonucleoprotein …

WebApr 11, 2024 · This delay was due to the presence of misaligned chromosomes that ultimately satisfy the SAC and missegregate, leading to micronuclei formation. Mechanistically, it is shown that mitotic DNA damage causes missegregation of polar chromosomes due to the action of arm-ejection forces by chromokinesins. option outcome incorrectly specifiedWebSep 30, 2024 · The chromokinesin KIF22 uses plus end-directed motility and direct binding to chromosome arms to generate pushing forces that contribute to mitotic chromosome congression and alignment. Mutations in the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient … portland youth climate councilWebSep 21, 2011 · Interestingly, from its positioning on the chromosome arms, Hklp2 seems to restrict spindle pole separation. In the present review, we summarize the current knowledge of the function and regulation of the different kinesins associated with chromosome arms during cell division, including Hklp2 as a novel member of this so-called chromokinesin ... option p\u0026l attribution and pricingWebJun 27, 2024 · The chromokinesin KIF4A associates with microtubules and contributes to chromosome segregation during mitosis. Here, we show that this function depends on a … option overwriteschema trueWebMar 6, 2015 · The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J. Cell Biol. 154 , 1135–1146 (2001) . option out meaningWebMar 3, 2003 · Kid is a kinesin-like DNA-binding protein known to be involved in chromosome movement during mitosis, although its actual motor function has not been demonstrated. Here, we describe the initial … portland yellow cabWebJun 27, 2024 · Chromokinesin, Fe-S cluster, Genome stability INTRODUCTION Recent studies have attempted to expand the list of genes contributing to chromosome instability (CIN) in yeast. These studies resulted in the identification of many yeast CIN genes that can be organized into a number of functional groups. portland youth basketball