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WebThe CRISPR/Cas9 system is an efficient and direct strategy to generate stable MHC knockout cell lines such as tumor cell lines. The resulting MHCI/II-deficient cell lines can be used as parental lines for the establishment of MHC-compatible, transplantable tumor models in HLA transgenic mouse lines lacking expression of endogenous MHC molecules. WebDec 10, 2015 · Primary plasma cell leukemia (PCL) is a rare and aggressive variant of plasma cell myeloma (PCM) characterized by the presence of circulating plasma cells (PCs) with morphologic features of other myelomas, but often resembling plasmacytoid lymphocytes 1.Current diagnostic criteria require the enumeration of >20% and/or … Webcytosis: ( sī-tō'sis ), 1. A condition in which there is more than the usual number of cells, as in the cytosis of spinal fluid in acute leptomeningitis. 2. Frequently used with a prefixed … bug fifa 23 pc steam