Ethiofos

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August undefined, 2024

WebAn analytical method for the combined measurement of ethiofos (WR-2721) and a major metabolite (WR-1065) in plasma is described. Plasma samples were subjected to … WebLaura Ellen Millender, in Complications in Head and Neck Surgery (Second Edition), 2009. Amifostine. Amifostine is a radioprotectant and a free-radical scavenger that accumulates in the salivary glands. A multinational phase III study demonstrated that intravenous amifostine given concurrently with radiation therapy reduced the incidence of grade 2 or …

Purging of small cell lung cancer cells from human bone marrow

WebThe U.S. Department of Energy's Office of Scientific and Technical Information WebOther Name(s): , Ethiofos WHY is this medicine prescribed? Amifostine is used protect the kidneys from harmful effects of the chemotherapy drug cisplatin in patients … pbrip membership

Disposition of the radioprotector ethiofos in the rhesus monkey ...

WebJul 1, 1989 · Ethiofos did not protect CFU-GEMM from LAMP inhibition at 120 min. Ethiofos alone had no effect on the SCLC or hematopoietic cells. When normal bone marrow was contaminated with 1 or 5% SCLC cells, ethiofos plus 60 min of LAMP eliminated SCLC cells but had no effect on CFU-GEMM. The results suggest that … WebMay 1, 1989 · Plasma concentrations of ethiofos [S-2-(3-aminopropylamino)ethyl phosphorothioic acid, WR-2721] were compared following iv, ip, intraduodenal, and … WebSep 1, 2004 · Two cytoprotective agents, ethiofos (WR2721) and nerve growth factor (NGF), were used to diminish cisplatin-induced toxicity in Schwann cell cultures. pb rising stars mentorship

Ethiopia - The World Factbook

WebAfter an ip dose of either labeled or unlabeled ethiofos, absorption of the dose was prolonged, but AUC values for total radioactivity or ethiofos and total WR-1065 were similar to those observed after the corresponding 10-min iv experiments. For either iv or portal routes, increases in ethiofos AUC values were observed for the same total dose ... Ethiopia, officially the Federal Democratic Republic of Ethiopia, is a landlocked country in the Horn of Africa. It shares borders with Eritrea to the north, Djibouti to the northeast, Somalia to the east and northeast, Kenya to the south, South Sudan to the west, and Sudan to the northwest. Ethiopia has a total area of 1,100,000 square kilometres (420,000 square miles). As of 2024, it is home to around 11… scripture night seasonWebJan 7, 1991 · The sales force is tentatively scheduled to begin detailing on Jan. 28. The product will be distributed through wholesalers at a price not yet disclosed. U.S. Bioscience plans to scale-up the size of its sales force to about 30 reps in time for its next product launch, which will likely be for its radio-protective agent Ethyol (ethiofos). scripture new heart

"WebNov 1, 1987 · Ethiofos (WR-2721) is a free radical scavenger which appears to be preferentially taken up by normal cells relative to some tumor cells. WR-2721 has been assayed as a protector of the normal ... " - Ethiofos

Ethiofos

Ethiopia People, Flag, Religion, Capital, Map, Population, …

WebApr 1, 1993 · PROPERTIES OF WR2721 (ETHIOFOS) AS MODULATOR OF CISPLATIN-INDUCED NEUROTOXICITY STUDIED AT THE ULTRASTRUCTURAL LEVEL IN THE POND SNAIL LYMNAEA-STAGNALIS Authors: LJ MULLER CM MOORERVANDELFT M TRESKES JB VERMORKEN WJF VANDERVIJGH HH BOER View Affiliations Published … WebThe chemical reactivity of the modulating agent WR2721 (ethiofos) and its main metabolites with the antitumor agents cisplatin and carboplatin. Marco Treskes, Ulbe Holwerda, Ina Klein, Herbert M. Pinedo, Wim J F Van Der Vijgh. Research output: Contribution to journal › Article › peer-review.

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WebAmifostine Ethiofos Aminopropylaminoethyl Thiophosphate Apaetp Ethiofos Gammaphos SAPEP WR-1065, ({2-[(3-aminopropyl)amino]ethyl}sulfanyl)phosphonic acid Show More. Show Less. FORMULA. C23H36N6O5S Typical Product Specifications. MOLECULAR WEIGHT. 214.223. ASSAY/PURITY. Typically NLT 98%. CHEMICAL STRUCTURE ... WebSep 1, 2004 · Request PDF Effect of two different cytoprotectives, ethiofos and beta-NGF, on cisplatin-induced toxicity in Schwann cell cultures; a preliminary study Two cytoprotective agents, ethiofos ...

WebApr 16, 2008 · This method was successfully applied in dosing experiments with rhesus monkeys in which ethiofos was administered into the cephalic vein (IV), portal vein (P) and duodenum. In IV experiments total VR-1065 plasma concentrations greatly exceeded total cysteamine concentrations. While results indicate formation of free and bound … WebAmifostine, also known as the brand name Ethyol and as ethiofos or WR2721, is a medicine that helps protect certain tissues of the body from damage caused by chemotherapy or radiation therapy . Purpose Amifostine is a protectant agent that is used in combination with the chemotherapy drug cisplatin or in combination with radiation …

WebAfter an ip dose of either labeled or unlabeled ethiofos, absorption of the dose was prolonged, but AUC values for total radioactivity or ethiofos and total WR-1065 were … WebEthiofos is a white crystalline powder which is freely soluble in water. Its empirical formula is C 5 H 15 N 2 O 3 PS and it has a molecular weight of 214.22. Ethiofos is the trihydrate form of Ethiofos and is supplied as a sterile lyophilized powder requiring reconstitution …

WebDec 19, 2006 · A specific, sensitive high performance liquid Chromatographie method for ethiofos [S-2-(3-aminopropylamino)ethyl phosphorothioate, WR 2721, I] in plasma is …

WebETHIOFOS AMIFOSTINE TRIHYDRATE AMIFOSTINE ANHYDROUS AMINOPROPYLAMINOETHYL THIOPHOSPHATE SAPEP WR-1065 AMIFOSTINE ETHIOFOS AMIFOSTINUM APAETP AMIFOSTINA chemidplus:20537-88-6 rxcui:1545987 drugbank:01143 chembl:CHEMBL1006 pubchem.compound:2141 scripture new year blessings kjvWebJan 1, 1988 · However, ethiofos also produces nausea, vomiting, diarrhea, and hypotension, which implies severe behavioral consequences (Bogo et al., 1985). We studied the effects of ethiofos on behavior in monkeys and its ability to mitigate early transient incapacitation (ETI). ETI is the abrupt cessation of performance (for at least 1 ~min) … scripture new day dawningWebJul 1, 1989 · Ethiofos did not protect CFU-GEMM from LAMP inhibition at 120 min. Ethiofos alone had no effect on the SCLC or hematopoietic cells. When normal bone marrow was contaminated with 1 or 5% SCLC cells, ethiofos plus 60 min of LAMP eliminated SCLC cells but had no effect on CFU-GEMM. scripture new covenant in my bloodWebThis report contains results of the following studies Encapsulation of ethiofos WR 2721 for use as oral dosage forms. In vitro evaluation of the most promising samples. Development of analytical methodology for the active species. Preliminary pharmacokinetic results of in vivo studies. This report covers studies conducted on S-2-3-aminopropylaminoethyl … scripture nevertheless not thy will but thineWebChemotherapy is a general term for medications used to destroy or stop the growth of cancer cells. Your child's treatment plan will use the best medicine or combination of medicines available to most effectively combat your child's specific type and stage of cancer. This Children's Cancer and Chemotherapy video explains how cancer treatments are … scripture night lightsWebApr 11, 2024 · Ethiopia, country on the Horn of Africa. The country lies completely within the tropical latitudes and is relatively compact, with similar north-south and east-west … pbr in worcester maWebDec 19, 2006 · A specific, sensitive high performance liquid Chromatographie method for ethiofos [S-2- (3-aminopropylamino)ethyl phosphorothioate, WR 2721, I] in plasma is described. The detection limit is 0.05 (μg/mL (0.23 (μM). scripture no eye has seen nor ear heard